Tissue Engineering

Using tissue engineering, implants will be developed for the reconstruction or replacement of damaged organs. For this purpose, biological matrices and tissue-type-specific primary cells are used. The optimal replacement of diseased or damaged tissue (e.g. heart valves, vessels, vascular valves) is performed with autologous (patient-own) cells seeded on a matrix. At present, laboratory research focuses on cell and development biology, as well as on cell culture engineering. With currently available biomedical technologies, form and function of the bioartificial tissue will be "prefabricated" in vitro in a bioreactor. Subsequently, vital tissue will be implanted into patients to reach its final stability and full function in vivo, following maturation within the recipient’s body. The use of autologous cells from the implant recipient should:

  • minimize the danger of rejection,
  • make the use of immunosuppressive drugs  unnecessary,
  • exclude the transmission of infection agents,
  • ensure the ability of the implant to grow in step with the patient (eg. in the case of children)
Stem cell based bioartificial cardiac tissue
Tissue engineered heart valve