Interdisciplinary team finds new approaches for PCD research

 

Primary Ciliary Dyskinesia (PCD) is a very rare hereditary systemic disease, which leads, amongst other things, to secretion retention and, as a result, to chronic inflammation and often also chronic respiratory tract infection. Until now, further investigation into this disease has been hampered by the limited amount of cell material available for research. Thanks to interdisciplinary cooperation, BREATH scientists have now succeeded in producing induced pluripotent stem cells, with which unlimited amounts of test material can be manufactured.

 

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Modern high-throughput screening and stem cell technology support the search for CFTR modulators

Working gropup of Prof. Dr. Ulrich Martin (first on the right), Dr. Ruth Olmer (first from the left) und Dr. Sylvia Merkert (in the middle) Quelle: Karin Kaiser / MHH

 

The genetic lung disease cystic fibrosis has remained incurable up to now. Only for certain types of mutation has the first therapy for CFTR modulators (CFTR = cystic fibrosis transmembrane conductance regulator) been approved in Germany, allowing an etiological therapy of the disease-promoting defective CFTR ion channel. Scientists in the team led by Prof. Dr. Ulrich Martin and Dr. Ruth Olmer at Hannover Medical School (MHH) have developed a method of identifying further CFTR modulators using disease-specific induced pluripotent stem cells (iPSCs) in high-throughput screening.

 

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BREATH scientist develops protocol for the generation of clinically relevant amounts of endothelial cells

Dr. Ruth Olmer, Researcher at BREATH and working group leader at the LEBAO of the MHH.

 

Endothelial cells (ECs) are involved in a variety of cellular processes, e.g. the immune response, inflammation and regulation of blood flow. They are used in cell therapies and are an important component in the production of tissue constructs as well as in in vitro disease models. Although the isolation of primary ECs from different sources has been shown, the generation of sufficient cell levels in stable quality still remains a challenge. Ruth Olmer has now developed a scalable protocol for the generation of ECs from human induced pluripotent stem cells.

 

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Further reports can be found here.